The core of clinical practice guidelines is the recommendations, and the ideal situation for guidelines is an unequivocal body of evidence about the benefits and harms of different treatment options, and related costs and resources. However, when high quality evidence is lacking, a no guideline recommendation is the best recommendation in clinical practice, according to co-authors Michael Bretthauer, MD, PhD and Mette Kalager, MD, PhD, who published their comments in the September 15th edition of THE LANCET.
Dr. Soyeon Kim, a Senior Research Scientist at Frontier Science Boston, is co-author on an original article, Bacterial Factors in Relapse after Tuberculosis Therapy, published in the August 30, 2018 edition of the New England Journal of Medicine.
Stephen Hart, PhD, a Senior Research Scientist at Frontier Science Foundation (FSF), is the lead author of an article published in the September 1, 2018 edition of the Journal of Acquired Immune Deficiency Syndromes (JAIDS), “Impact of changes over time in the Stanford University genotypic resistance algorithm.” The article comes out of ACTG Data Analysis Concept Sheet (DACS) 330, which Steve designed and led. Sarah Strobino, BS, also from Frontier Science Foundation, made major contributions to the project. Saran Vardhanabhuti, PhD and Linda J. Harrison, MSc, from Harvard T.H. Chan School of Public Health, did the trend analysis.
The 10th International Workshop on HIV Pediatrics, held July 20 to 21, 2018 in Amsterdam, The Netherlands, is entirely devoted to research in prevention and treatment of HIV infections in infants, children and adolescents, making it a premier forum for the world’s leading experts in pediatric, adolescent and maternal HIV research. The 22nd International AIDS Conference, also held in Amsterdam, from July 23 to 27, is the world’s largest conference on AIDS, biennially bringing together leading experts to advance knowledge about HIV. Several networks with whom Frontier Science collaborates, including the IMPAACT, ACTG, and PHACS networks, were highlighted in Amsterdam this year, and Frontier Science was acknowledged as one of the affiliated organizations working on the HIV studies.
Dr. Soyeon Kim, Senior Research Scientist, joined Frontier Science Foundation Boston office in September 2017. Soyeon has worked in the design, analysis, monitoring, and reporting of clinical research studies with International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) and its predecessor Pediatric AIDS Clinical Trials Network, as well as investigator-initiated projects, for more than 20 years. She enjoys working in multidisciplinary teams, closely collaborating with investigators to design trials of clinical and public health significance.
Michael Bretthauer, Frontier Science Foundation President, has announced key features of a new business development plan for Frontier Science in the coming years that will maintain and develop current business platforms and areas, and explore and establish more diverse funding sources and collaborations. The first step in this future development plan is the establishment of a leadership structure to meet the opportunities ahead, including a new Executive Director.
A Norwegian pilot study published in the June 2, 2018 edition of the New England Journal of Medicine shows that a supply of intestinal bacteria can be better than antibiotics for all patients with Clostridium difficile Infection, including those who have it for the first time. The study, Fecal Microbiota Transplantation for Primary Clostridial Difficile Infection examined whether the intestinal bacterial infections of a healthy person (fecal microbial transplantation) can restore a healthy and resilient intestinal flora so that the patient with C Diff infection can get rid of the infection without resorting to antibiotics.
Frontier Science Amherst staff presented two posters at the Society For Clinical Trials 2018 annual meeting. A Unique Collaboration for a Data Coordinating Center outlines the INVESTED collaboration between the University of Wisconsin-Madison and the Frontier Science Data Management Center. Calculating Antiretroviral Drug Resistance: An Innovative Open-Source Tool showcases an antiretroviral drug resistance calculations tool developed at Frontier Science that uses customizable algorithms.
The Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) invite you to attend an IAS pre-conference in Amsterdam, the Netherlands, on July 22 from 12-2pm CET entitled Blood, Guts & Glory: HIV & Substance Use Research Opportunities Using the C3PNO Virtual Repository to Link NIDA Cohort Data.
C3PNO, the data coordinating center for the National Institute on Drug Abuse (NIDA) longitudinal HIV cohorts, will demonstrate and discuss opportunities related to the new C3PNO virtual repository which links laboratory, clinical, substance use, behavioral, and biological data. The C3PNO goal is to stimulate research with outside investigators and encourage new collaborations with international cohorts studying substance use in the context of HIV pathogenesis. Representatives from Frontier Science will include: Dr. Soyeon Kim, Senior Biostatistician, Adina Stoica, Software Project Manager and Sue Siminski, Co-Principal Investigator.
Members of the Norwegian Colorectal Cancer Prevention Study Group (NORCCAP), including Michael Bretthauer, Frontier Science President, and Mette Kalager, MD, PhD, Board Member, have authored a study published April 24, 2018 in the Annals of Internal Medicine, Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A randomized trial. The study objective is to determine the effectiveness of flexible sigmoidoscopy screening after 15 years of follow-up in women and men.
The Frontier Science Independent Statistical Center, or ISC, has launched a new website at http://www.fstrf-isc.org. The website outlines the Frontier Science ISC areas of expertise and experience, and the graphical reporting style of the ISC.
Frontier Science is pleased to announce C3PNO, a partnership with the University of California, Los Angeles (UCLA) to stimulate new research in the areas of HIV/AIDS infection in the context of substance abuse.
Laurie Dooley Butler, Data Manager for the Pediatric HIV/AIDS Cohort Study (PHACS)
Our “Employee Spotlight” shines on Laurie Dooley Butler, Data Manager for the Pediatric HIV/AIDS Cohort Study (PHACS). Laurie has worked at Frontier Science for fourteen years. She has an undergraduate degree in Medical Technology from Daemen College, and an MBA from the State University of New York at Buffalo.
Announcing the 2018 DFCI/FSTRF Marvin Zelen Memorial Symposium, to be held on Friday April 6, 2018 from 1:00-6:00pm at the Dana-Farber Cancer Institute.
The topic this year is Data Science in Biomedical Research.
Speakers for this year include:
- Barbara Englehardt, Ph.D., Assistant Professor, Department of Computer Science, Princeton University
- Jeffrey Leek, Ph.D., Associate Professor, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
- Steve Goodman, M.D., MHS, Ph.D., Professor of Medicine and of Health Research and Policy, Stanford University
- JJ Allaire, Founder and CEO of RStudio
- Fernanda Viegas, Co-leader, Google’s “Big Picture” Data Visualization Group
- Jayashree Kalpathy-Cramer, Associate Professor of Radiology, Massachusetts General Hospital
Meredith Regan, Sc.D., Director of the Statistical and Data Management Center for the International Breast Cancer Study Group (IBCSG) and co-lead for the IBCSG TEXT and SOFT Trials, visited Frontier Science to present the results of several trials. These results were recently presented during the San Antonio Breast Cancer Symposium (SABCS 2017).
Jamie Hoel, MS, has been named the new Director of the Madison Office of Frontier Science, President Michael Bretthauer announced today. “I am absolutely convinced that Jamie will fill this important role with success, and ask you to welcome him and support him the best you can in his new position,” said Dr. Bretthauer.
Lynette Blacher, Director of Data Management for the International Breast Cancer Study Group (IBCSG)
We are pleased to present a new “Employee Spotlight” series at the Frontier Science website. Lynette Blacher, Director of Data Management for the International Breast Cancer Study Group (IBCSG), has worked at Frontier Science for twenty years. Her educational background includes an undergraduate degree in Psychology and a Masters in Information and Library Science (MLS), both from the State University of New York at Buffalo.
On November 22, the U.S. Food and Drug Administration (FDA) approved updates to the label for raltegravir (also known by the brand name Isentress). This change expands the patient population to include HIV-1 exposed full term neonates from birth to four weeks of age.
Raltegravir is a potent and selective HIV-1 integrase inhibitor. It is used as a treatment for HIV/AIDS, and can also be used as part of a post exposure prophylaxis (PEP).
The change to the label was based on data from the International Material Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) study P1110. Frontier Science, along with the Harvard T.H. Chan School of Public Health, provide data management and statistical support for this study. The quote below is from the the IMPAACT announcement.
In a December 6, 2017 editorial on Breast cancer screening in The BMJ, Frontier Science board member and Associate Professor at University of Oslo Clinical Effectiveness Research Group, Dr. Mette Kalager, looks at studies analyzing data on breast cancer mortality, mammography screening, and over-diagnosis, and references a new study in the same edition at BMJ, Effectiveness of and overdiagnosis from mammography screening in the Netherlands: population based study. BMJ 2017;359:j5224.
Since its inception, Frontier Science has always viewed its statistical data management services as a collaborative effort, helping researchers and investigators understand and best utilize the data that they are using. As part of this commitment, Dr. Michael Bretthauer brings a diverse academic, research, and publication experience into Frontier Science’s core management.